MiRNAs and miRNA Polymorphisms Modify Drug Response
نویسندگان
چکیده
منابع مشابه
MiRNAs and miRNA Polymorphisms Modify Drug Response
Differences in expression of drug response-related genes contribute to inter-individual variation in drugs' biological effects. MicroRNAs (miRNAs) are small noncoding RNAs emerging as new players in epigenetic regulation of gene expression at post-transcriptional level. MiRNAs regulate the expression of genes involved in drug metabolism, drug transportation, drug targets and downstream signal m...
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Individuals vary widely in their response to drug treatment. After receiving doses of a drug that are recommended based on a population average, some patients could have an insufficient response, whereas others may experience adverse effects. Of the many factors causing variability in drug response across individuals, genetic polymorphism of drug-metabolizing enzymes is deemed to be one of the ...
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ژورنال
عنوان ژورنال: International Journal of Environmental Research and Public Health
سال: 2016
ISSN: 1660-4601
DOI: 10.3390/ijerph13111096